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Vaccine pills coming soon? | BioQuality.biz

Vaccine Pills would be real shot in the arm for vaccine industry šŸ˜‰

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Effect of protein release rates from tablet formulations on the immune response after sublingual immunization

Borde A, Ekman A, Holmgren J, Larsson A., Eur J Pharm Sci. 2012 Aug 29. [Epub ahead of print], Pharmaceutical Technology, Chemical and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.

Synopsis:

  • This paper details research towards realization of dry vaccine formulations for sublingual administration, which would beĀ  great boon to both patients and industry “since they are easy to administer and might also have improved stability properties.”
  • This paper presents research using the model protein OvalbuminĀ in BALB/c miceĀ to determineĀ “the influence of protein release rate from mucoadhesive two-layer tablets on the elicited antibody responses after sublingual immunization.”
  • The authors studied 5 tablet types:
    • Two fast release tablets, one based on a mixture of lactose and microcrystalline cellulose (MCC) and one protein coated ethylcellulose (EC) tablet
    • Three hydrophilic matrix tablets with extended release (ER) properties based on HPMC 90 SH 100000 or CarbopolĀ® 974-P NF
  • What they measured was the in vitro release profiles of the model protein ovalbumin (OVA) from these tablets
  • This was then characterized and correlated to the in vivo potential of the tablets to induce an immune response after sublingual immunization in the BALB/c mice
  • According to the authors, “It could be concluded that a tablet with fast protein release elicits antibody titres not significantly different from titres obtained with OVA in solution, whereas low immune responses were observed with a slow release of OVA from the ER formulations.”
  • Their conclusions:
    • ER tablets seem not favorable for vaccine delivery to the sublingual mucosa
    • AĀ fast releasing tablet formulationĀ has attractive features for sublingual immunization
    • And, of course, that universal statement of all researchers everywhere: “…the use of ER formulations for sublingual vaccination has to be investigated more in detail”

To see the Abstract, and a link to obtain this paper: http://www.ncbi.nlm.nih.gov/pubmed/22959953

 

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